However, as indicated above, the salvage pathway to thymidine nucleotide synthesis is especially important in the preparation for cell division. The salvage of pyrimidine bases has less clinical significance than that of the purines, owing to the solubility of the by-products of pyrimidine catabolism. (2) Salvage process i.e. sary for the synthesis of RNA, DNA, nucleotide-activated sugars, and lipids [3]. In this system, both the salvage precursors [ 3 H]thymidine and [ 14 C]cytidine were incorporated actively into skin DNA and only [ 14 C]cytidine into skin RNA. Salvage pathway (recycle pathway): used to recover bases and nucleosides formed during the degradation of RNA and DNA Nucleotide Synthesis (De-novo and Salvage Pathways of Purine & Pyrimidine Biosynthesis PPT by easybiologyclass) 1. APRT is inhibited by AMP. UMP, which is used to synthesize UDP, UTP, dTTP, CTP, and dCTP, is the common metabolite between the de novo and the salvage pyrimidine synthesis pathway. NUCLEOTIDE BIOSYNTHESIS Bio-synthesis of Purines & Pyrimidines e-mail: easybiologyclass@gmail.com mail@easybiologyclass.com www.easybiologyclass.com www.easybiologyclass.com A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. De Novo Synthesis: De novo (all over again) synthesis of purine nucleotides is synthesis of purines anew. Uridine monophosphate, or UMP, is used as the example of the pyrimidine nucleotide. Understand the Two Pathways of nucleotide biosynthesis (1) De-novo synthesis and (2) Salvage Pathways. recycling of the bases. De novo synthesis of nucleotides does not take place in brain and erythrocytes, making salvage pathway indispensable for them The salvage pathway requires no ATP and accounts for 90% of nucleotide biosynthesis. This pathway supplies ribose sugar for the formation of the nucleotide. attached to the ribose sugar provided from HMP pathway. I. De-novo synthesis (synthesis from scratch): it is a biochemical pathway in which nucleotides are synthesized new from simple precursor molecules. (1) de-novo synthesis and (2) synthesis by salvage pathways. Its regulation occurs by competitive inhibition by IMP and GMP. The pyrimidine synthesis is a similar process than that of Purines(Purines Synthesis).In the de novo synthesis of Pyrimidines, the ring is synthesized first and then it is attached to a ribose-phosphate to for a pyrimidine nucleotide.Pyrimidine rings are assembled from bicarbonate, aspartate, and Ammonia. Each category has at least one description. The purine ring is synthesized along with the nucleotide i.e. II. HGPRT is the most important salvage enzyme. 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